Ia and Schistosoma haematobium co-infection was also reported [21]. While protozoa infection was predominant in the present study, it can be generally believed that in helminth infection the kind two T helper (Th2) response induced by helminths could alter the natural immune response from the host to Plasmodium, as a consequence of the antiinflammatory effect of cytokines induced by helminths. Nonetheless, the cytokine profile of this population have already been published and for malaria-infected men and women (MS chezArcila et al. Malar J (2015) 14:Web page ten ofand CI groups) the profile showed high levels of IL-1, IL-6, TNF, IL-10, and CRP and decreased levels of IL17A even though for malaria-negative men and women (IP and N) the profile was higher levels of IL-17A, NO and decreased levels of IL-10 and CRP [20]. Thus, it appears that intestinal parasites co-infection (mainly protozoan) doesn’t influence the plasmatic cytokine levels of acute malariainfected people.Received: 14 April 2015 Accepted: 29 OctoberConclusions The presence of antibody responses to each P. vivax AMA-1 and MSP-1 proteins in all groups indicated that the participants had been exposed to malaria infection along with the IgG subclass responses have been largely in agreement with previously published benefits. Despite the fact that in the present operate there had been adjustments in total IgG directed to PvAMA1 and PvMSP-119 in Intestinal parasites group, a reduce in IgG and in cytophilic responses connected to co-infections was not observed. These responses may perhaps relate to other factors including antigen properties, number and time of exposure, host age and genetic determinants. Further studies ought to be conducted to establish the impact of intestinal protozoa within the immune response to malaria antigens.165617-59-4 Data Sheet Authors’ contributions JOF conceived and supervised the study.Vanadium(IV)bis(acetylacetonato)oxide Chemical name JOF and DMB developed the study. Fieldwork and sample collection was performed by JOF, JCSA, JCLJ, DSPS, MPAV JRN, CJLA, and DMB; JCSA, MMF, VAP, and JCSA carried out the experi ments. MMR and ISS produced the recombinant proteins. Information had been collected and analysed by JCSA and MMF with help from JOF. The initial draft of this manuscript was written by JCSA and MMF; JOF critically study and advised on the manuscript. All authors study and authorized the final version and agreed to the submission. All authors study and approved the final manuscript. Author specifics 1 Laboratorio de Imunoparasitologia, Instituto Oswaldo Cruz, Funda o Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil. two Instituto de Infectologia Em io Ribas, S Paulo, Brazil. 3 Laborat io de Imunodiagn tico, Departamento de Ci cias Biol icas, Escola Nacional de Sa e P lica/ Fiocruz, Rio de Janeiro, Brazil.PMID:35116795 four Laborat io de Simul eos e Oncocercose, Insti tuto Oswaldo Cruz, Funda o Oswaldo Cruz, Rio de Janeiro, Brazil. five Intituto de Gastroenterologia de Goi ia, Goi ia, Goi , Brazil. six Agencia de Vigil cia em Sa e da Secretaria de Estado da Sa e AGEVISA, Rondonia, Brazil. 7 Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de S Paulo, Escola Paulista de Medicina, S Paulo, Brazil. 8 Departamento de An ises Cl icas e Toxicol icas, Faculdadede Ci cias Farmac ticas, Universidade de S Paulo, S Paulo, Brazil. Acknowledgements The authors are in debt for the people who participated in this study, the Secretary of Health and Laboratory Central (LACEN) of Rondonia, the neighborhood malaria control team in Joana D rc settlement for their logistic help and also the Institute Oswaldo Cruz (.