= 1,383,154 person-years) HR 95 CI Pack-years Smoked Ahead of Age 30 Years 1? (n = 1,085,062 person-years) HR 95 CI ten (n = 560,470 person-years) HR 95 CI Ptrendb Pheterogeneity c 20 (n = 744,382 person-years) HR 95 CI Age at Get started of Smoking, years 20 (n = 976,780 person-years) HR 95 CI Ptrendb Pheterogeneity contact colorectal cancer No. Age-adjusted Multivariated CIMP status CIMP-low/negative No. Age-adjusted Multivariated CIMP-high No. Age-adjusted Multivariated MSI status MSS No. Age-adjusted Multivariated MSI-high No. Age-adjusted Multivariated BRAF mutation status BRAF-wildtype No. Age-adjusted Multivariate No. Age-adjusted Multivariated d490 1.00 1.00 Referent Referent 1.09 1.414 0.96, 1.25 0.92, 1.20 1.31 1.300 1.14, 1.52 1.08, 1.45 0.0002 0.003 0.09 1.16 1.347 1.01, 1.33 0.97, 1.29 1.21 1.402 1.06, 1.38 1.01, 1.33 0.004 0.03 0.377 1.00 1.00 Referent Referent 71 1.00 1.00 Referent Referent 1.33 1.29 1.16 1.322 1.00, 1.35 0.96, 1.31 74 0.96, 1.85 0.93, 1.79 1.62 1.54 1.13 1.222 0.95, 1.34 0.90, 1.28 50 1.11, 2.35 1.06, 2.25 0.01 0.02 0.05 1.27 1.23 0.09 0.30 1.19 1.274 1.01, 1.39 0.98, 1.35 57 0.89, 1.80 0.87, 1.75 1.50 1.44 1.16 1.301 0.99, 1.35 0.95, 1.30 71 1.08, two.09 1.03, 2.01 0.02 0.03 0.21 0.05 0.400 1.00 1.00 Referent Referent 63 1.00 1.00 Referent Referent 1.58 1.53 1.10 1.323 0.95, 1.28 0.92, 1.24 75 1.12, two.21 1.09, 2.15 1.61 1.55 1.13 1.240 0.96, 1.33 0.91, 1.27 45 1.09, 2.40 1.04, 2.31 0.01 0.01 0.39 1.62 1.57 0.ten 0.32 1.11 1.275 0.95, 1.29 0.92, 1.26 63 1.14, 2.30 1.11, 2.24 1.45 1.39 1.15 1.318 0.99, 1.33 0.94, 1.28 60 1.01, two.06 0.97, 1.99 0.03 0.06 0.73 0.07 0.Am J Epidemiol. 2013;178(1):84?404 1.00 1.00 Referent Referent 67 1.346704-04-9 site 00 1.494767-19-0 Order 00 Referent Referent 1.25 1.21 1.14 1.334 0.99, 1.32 0.95, 1.28 68 0.89, 1.75 0.86, 1.71 1.35 1.29 1.16 1.253 0.99, 1.37 0.94, 1.31 37 0.89, two.04 0.85, 1.96 0.08 0.13 0.41 1.30 1.26 0.03 0.15 1.15 1.289 0.99, 1.34 0.96, 1.31 53 0.90, 1.86 0.88, 1.82 1.24 1.20 1.17 1.328 1.01, 1.36 0.97, 1.31 56 0.87, 1.78 0.83, 1.72 0.21 0.30 0.07 Table continues 0.03 0.BRAF-mutatedDNMT3B expression statusAm J Epidemiol. 2013;178(1):84?Table five. ContinuedNever Smoker (n = 1,383,154 person-years) HR 95 CI Pack-years Smoked Prior to Age 30 Years 1? (n = 1,085,062 person-years) HR 95 CI ten (n = 560,470 person-years) HR 95 CI Ptrendb Pheterogeneity c 20 (n = 744,382 person-years) HR 95 CI Age at Start of Smoking, years 20 (n = 976,780 person-years) HR 95 CI Ptrendb Pheterogeneity cDNMT3B-negative No.PMID:25429455 Age-adjusted Multivariate No. Age-adjusted Multivariated d238 1.00 1.00 Referent Referent 52 1.00 1.00 Referent Referent 0.67 0.65 1.23 1.222 1.02, 1.48 0.99, 1.45 27 0.42, 1.08 0.41, 1.04 0.93 0.87 1.09 1.131 0.87, 1.35 0.83, 1.30 24 0.56, 1.53 0.53, 1.45 0.72 0.53 0.82 0.80 0.25 0.54 1.21 1.179 1.00, 1.48 0.97, 1.45 27 0.52, 1.32 0.50, 1.28 0.76 0.72 1.17 1.191 0.97, 1.42 0.92, 1.37 28 0.48, 1.21 0.45, 1.15 0.23 0.15 0.08 0.DNMT3B-positiveSmoking Cessation and Colorectal Cancer EpigeneticsAbbreviations: CI, self-confidence interval; CIMP, CpG island methylator phenotype; DNMT3B, DNA methyltransferase 3B; HR, hazard ratio; MSI, microsatellite instability; MSS, microsatellite steady. a All models have been stratified by calendar year of your questionnaire cycle, age, and sex. b Primarily based around the linear trend test by utilizing the median value of each and every category. c Tests for heterogeneity (for a multivariate HR linear trend) in the associations of smoking with a single molecular subtype versus the other molecular subtype (i.e., CIMP-.